RNA Details
Disease Name
aortic coarctation
Tissue
heart
RNA Symbol
mir-122
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
PCR; immunohistochemistry etc.
Target
NA
Pathway
NA
PubMed ID
Title
MicroRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-B1 up-regulation
Year
2014
Function
"miR-122 was inversely correlated with the CVF, TGF-beta1 and the TGF-beta1-regulated PCPE-1 (procollagen c-terminal proteinase enhancer-1),myocardial down-regulation of miR-122 might be involved in myocardial fibrosis in as patients, probably through TGF-beta1 up-regulation."